| Team | W | L | T | Streak |
| Cardinals | 10 | 6 | 0 | W1 |
| 49ers | 8 | 8 | 0 | L1 |
| Seahawks | 5 | 11 | 0 | W2 |
| Rams | 1 | 15 | 0 | L4 |
| Schedule 2010 | |||||
| WK | Date | Opp | Result | ||
| 1 | 9/12 | @ Sea | |||
| 2 | 9/20 | vs. NO | |||
| 3 | 9/26 | @ KC | |||
| 4 | 10/3 | @ Atl | |||
| 5 | 10/10 | vs. Phi | |||
| 6 | 10/17 | vs. Oak | |||
| 7 | 10/24 | @ Car | |||
| 8 | 10/31 | vs. Den | |||
| 9 | Bye Week | ||||
| 10 | 11/14 | vs. StL | |||
| 11 | 11/21 | vs. TB | |||
| 12 | 11/29 | @ Ari | |||
| 13 | 12/5 | @ GB | |||
| 14 | 12/12 | vs. Sea | |||
| 15 | 12/16 | @ SD | |||
| 16 | 12/26 | @ StL | |||
| 17 | 1/2 | vs. Ari | |||
| # | Name | Pos. | College | Acquired |
| 35 | Adams, Phillip | CB | South Carolina State | 2010- 7th Round |
| 9 | Andrus, Shane | PK/P | Murray State | 2009-FA(IND) |
| 64 | Baas, David | C/OG | Michigan | 2005-2nd Round |
| 48 | Balogun, Mike | ILB | Oklahoma | 2010- UDFA |
| 75 | Boone, Alex | RT | Ohio State | 2009- UDFA |
| 53 | Bowman, Navorro | ILB | Penn State | 2010- 3rd Round |
| 50 | Briggs, Diyral | OLB | Bowling Green | 2009- UDFA |
| 26 | Brock, Tramaine | CB | Belhaven | 2010- UDFA |
| 55 | Brooks, Ahmad | OLB | Virginia | 2008- W(Cincinnati) |
| 3 | Brown, Jarrett | QB | West Virginia | 2010- UDFA |
| 25 | Brown, Tarell | RCB | Texas | 2007-5th round |
| 82 | Byham, Nate | TE | Pittsburgh | 2010- 6th Round |
| 5 | Carr, David | QB | Fresno State | 2010- UFA(NYG) |
| 43 | Caulcrick, Jehuu | FB | Michigan State | 2010- Free Agent |
| 22 | Clements, Nate | LCB | Ohio State | 2007-UFA (Buffalo) |
| 15 | Crabtree, Michael | WR | Texas Tech | 2009- 1st Round |
| 88 | Curtis, Tony | TE | Portland State | 2010- FA |
| 76 | Davis, Anthony | RT | Rutgers | 2010- 1st Round |
| 47 | Davis, Bruce | OLB | UCLA | 2010-FA |
| 7 | Davis, Nate | QB | Ball State | 2009- 5th Round |
| 85 | Davis, Vernon | TE | Maryland | 2006-1st Round |
| 60 | De La Puente, Brian | OG | California | 2008-UDFA |
| 33 | Dixon, Anthony | RB | Mississippi State | 2010- 6th Round |
| 93 | Evans, Demetric | DE | Georgia | 2009- UFA(Washington) |
| 49 | Finley, Joe Jon | TE | Oklahoma | 2008- UDFA |
| 92 | Franklin, Aubrayo | NT | Tennessee | 2007-UFA (Baltimore) |
| 19 | Ginn Jr., Ted | WR | Ohio State | 2010- T/MIA |
| 38 | Goldson, Dashon | FS | Washington | 2007-4th Round |
| 21 | Gore, Frank | RB | Miami (FL) | 2005-3rd Round |
| 18 | Guillory, Bobby | WR | Central Missouri | 2010-UDFA |
| 98 | Haralson, Parys | ROLB | Tennessee | 2006-5th Round |
| 66 | Heitmann, Eric | C | Stanford | 2002-7th Round |
| 89 | Hill, Jason | WR | Washington State | 2007-3rd round |
| 77 | Iupati, Mike | OG | Idaho | 2010- 1st Round |
| 31 | James, William | CB | Western Illinois | 2010-UFA(DET) |
| 95 | Jean-Francois, Ricky | NT | LSU | 2009- 7th Round |
| 86 | Jennings, Brian | LS | Arizona State | 2000-7th Round |
| 14 | Jurovich, Kevin | WR | San Jose State | 2010-UDFA |
| 71 | Kopa, Matt | OL/DL | Utah | 2010-UDFA |
| 45 | Kristick, Keaton | OLB | Oregon State | 2010- UDFA |
| 54 | LaBoy, Travis | OLB | Hawaii | 2010- Free Agent |
| 99 | Lawson, Manny | LOLB | North Carolina State | 2006-1st Round |
| 4 | Lee, Andy | P | Pittsburgh | 2004-6th Round |
| 32 | Lewis, Michael | SS | Colorado | 2007-UFA (Philadelphia) |
| 40 | Maragos, Chris | FS | Wisconsin | 2010- UDFA |
| 23 | Mays, Taylor | SS | USC | 2010- 2nd Round |
| 91 | McDonald, Ray | DE | Florida | 2007-3rd round |
| 47 | Miller, Brit | FB | Illinois | 2009-UDFA |
| 60 | Mitchelll, Khalif | NT | East Carolina | 2009- UDFA |
| 84 | Morgan, Josh | WR | Virginia Tech | 2008- 6th Round |
| 6 | Nedney, Joe | PK | San Jose State | 2005-UFA (Tennessee) |
| 44 | Norris, Moran | FB | Kansas | 2006-UFA (Houston) |
| 41 | Paymah, Karl | CB | Washington State | 2010- UFA(MIN) |
| 62 | Rachal, Chilo | RG | USC | 2008- 2nd Round |
| 24 | Robinson, Michael | RB/FB | Penn State | 2006-4th Round |
| 65 | Sims, Barry | RT | Utah | 2008- FA(Oakland) |
| 11 | Smith, Alex | QB | Utah | 2005-1st Round |
| 94 | Smith, Justin | DE | Missouri | 2008- UFA(Cincinnati) |
| 30 | Smith, Reggie | SS | Oklahoma | 2008- 3rd Round |
| 68 | Snyder, Adam | OG | Oregon | 2005-3rd Round |
| 90 | Sopoaga, Isaac | DE | Hawaii | 2004-4th Round |
| 36 | Spencer, Shawntae | CB | Pittsburgh | 2004-2nd Round |
| 51 | Spikes, Takeo | ILB | Auburn | 2008- FA(Philadelphia) |
| 74 | Staley, Joe | LT | Central Michigan | 2007-1st round |
| 28 | Taylor, Curtis | FS | Louisiana State | 2009- 7th Round |
| 63 | Tukafua, Will | DE/DT | Oregon | 2010-FA |
| 46 | Walker, Delanie | TE | Central Missouri State | 2006-6th Round |
| 78 | Walker, Derek | DE | Illinois | 2009- W/SEA |
| 59 | Wallace, Cody | C | Texas A&M | 2008- 4th Round |
| 20 | Westbrook, Brian | RB | Villanova | 2010-FA(PHI) |
| 57 | Wilhelm, Matt | ILB | Ohio State | 2009-FA(San Diego) |
| 10 | Williams, Kyle | WR | Arizona State | 2010- 6th Round |
| 52 | Willis, Patrick | RILB | Ole Miss. | 2007-1st round |
| 69 | Wragge, Tony | C | New Mexico State | 2005-UFA signed from Los Angeles (Arena) |
| 17 | Zeigler, Dominique | WR | Baylor | 2007-UDFA |
| # | Name | Pos. | College | Acquired |
| # | Name | Pos. | College | Acquired |
| 58 | Burnett, Martail | OLB | Utah | 2009-FA |
| 49 | Long, Brandon | OLB | Michigan State | 2010- FA |
| 56 | McKillop, Scott | ILB | Pittsburgh | 2009- 5th Round |
| 61 | Patrick, Chris | OT | Nebraska | 2009-PS(Kansas City) |
| # | Name | Pos. | College | Acquired |
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