| Team | W | L |
| 49ers | 13 | 3 |
| Cardinals | 8 | 8 |
| Seahawks | 7 | 9 |
| Rams | 2 | 14 |
| Pre | |||
| 12-Aug | @Saints | L | 3-24 |
| 20-Aug | Raiders | W | 17-3 |
| 27-Aug | Texans | L | 7-30 |
| 1-Sep | @Chargers | W | 20-17 |
| Reg | |||
| 11-Sep | Seahawks | W | 33-17 |
| 18-Sep | Cowboys | L | 24-27 |
| 25-Sep | @Bengals | W | 13-8 |
| 2-Oct | @Eagles | W | 24-23 |
| 9-Oct | Buccaneers | W | 48-3 |
| 16-Oct | @Lions | W | 25-19 |
| 30-Oct | Browns | W | 20-10 |
| 6-Nov | @Redskins | W | 19-11 |
| 13-Nov | Giants | W | 27-20 |
| 20-Nov | Cardinals | W | 23-7 |
| 24-Nov | @Ravens | L | 6-16 |
| 4-Dec | Rams | W | 26-0 |
| 11-Dec | @Cardinals | L | 19-21 |
| 19-Dec | Steelers | W | 20-3 |
| 24-Dec | @Seahawks | W | 19-17 |
| 1-Jan | @Rams | W | 34-27 |
| # | Name | Pos. | College | Acquired | Signed |
| 0 | Elmore, Ricky | OLB | Arizona | 2011-FA | |
| 11 | Smith, Alex | QB | Utah | 2005-1st Round | |
| 18 | Swain, Brett | WR | San Diego State | 2011-FA(GB) | |
| 19 | Ginn Jr., Ted | WR | Ohio State | 2010-T/MIA | |
| 20 | Williams, Madieu | FS | Maryland | 2011-FA(MIN) | |
| 22 | Rogers, Carlos | CB | LSU | 2011-UFA(WSH) | |
| 26 | Brock, Tramaine | CB | Belhaven | 2010-UDFA | |
| 27 | Spillman, C.J. | SS | Marshall | 2010-FA | |
| 30 | Smith, Reggie | FS | Oklahoma | 2008-3rd Round | |
| 38 | Goldson, Dashon | FS | Washington | 2007-4th Round | |
| 44 | Norris, Moran | FB | Kansas | 2006-UFA (Houston) | |
| 47 | Davis, Bruce | OLB | UCLA | ||
| 50 | Simmons, Monte | OLB | Kent State | 2011-UDFA | |
| 51 | Costanzo, Blake | ILB | Lafayette | 2011-UFA(CLE) | |
| 54 | Grant, Larry | ILB | Ohio State | 2011-FA(STL) | |
| 55 | Brooks, Ahmad | OLB | Virginia | 2008-W(CIN) | |
| 56 | Gooden, Tavares | ILB | Miami (FL) | 2011-FA(BAL) | |
| 62 | Rachal, Chilo | RG | USC | 2008-2nd Round | |
| 68 | Snyder, Adam | RG | Oregon | 2005-3rd Round | |
| 81 | Peelle, Justin | TE | Oregon | 2011-FA(ATL) | |
| 84 | Morgan, Joshua | WR | Virginia Tech | 2008- 6th Round | |
| 92 | Tukuafu, Will | DE | Oregon | 2010-FA |
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